BAIT
AMPH
AMPH1
amphiphysin
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BIN1
ALP-1, Amphl, BRAMP-2, SH3P9
bridging integrator 1
GO Process (8)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- lipid tube assembly [ISO]
- muscle cell differentiation [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of endocytosis [ISO]
- regulation of cell cycle arrest [ISO]
- regulation of neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
Neurofibrillary tangles composed of hyperphosphorylated tau and synaptic dysfunction are characteristics of Alzheimer's disease (AD). However, the underlying molecular mechanisms remain poorly understood. Here, we identified Amphiphysin I mediates both tau phosphorylation and synaptic dysfunction in AD. Amphiphysin I is cleaved by a cysteine proteinase asparagine endopeptidase (AEP) at N278 in the brains of AD patients. The amount of AEP-generated ... [more]
Elife Dec. 21, 2020; 10(); [Pubmed: 34018922]
Throughput
- Low Throughput
Curated By
- BioGRID