BAIT
DDB1
127kDa, AA408517, p127-Ddb1
damage specific DNA binding protein 1
GO Process (8)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
- UV-damage excision repair [ISO]
- Wnt signaling pathway [IDA]
- histone H2A monoubiquitination [ISO]
- negative regulation of apoptotic process [IMP]
- nucleotide-excision repair [IBA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of mitotic cell cycle phase transition [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
EIF4A3
2400003O03Rik, Ddx48, eIF4A-III, mKIAA0111, RP23-13O17.1
eukaryotic translation initiation factor 4A3
GO Process (7)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- embryonic cranial skeleton morphogenesis [ISO]
- negative regulation of translation [ISO]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [ISO]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of translation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
Obesity has become a global pandemic. Identification of key factors in adipogenesis helps to tackle obesity and related metabolic diseases. Here, we show that DDB1 binds the histone reader BRWD3 to promote adipogenesis and diet-induced obesity. Although typically recognized as a component of the CUL4-RING E3 ubiquitin ligase complex, DDB1 stimulates adipogenesis independently of CUL4. A DDB1 mutant that does ... [more]
Cell Rep Dec. 22, 2020; 35(12);109281 [Pubmed: 34161765]
Throughput
- Low Throughput
Curated By
- BioGRID