IMMT
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDE2A
Gene Ontology Biological Process
- cAMP catabolic process [IDA, ISO]
- cAMP-mediated signaling [IMP, ISO]
- cGMP catabolic process [IDA, ISO]
- cGMP-mediated signaling [ISO, ISS]
- cellular response to cGMP [ISO, ISS]
- cellular response to drug [ISO, ISS]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO, ISS]
- cellular response to macrophage colony-stimulating factor stimulus [ISO, ISS]
- cellular response to mechanical stimulus [ISO, ISS]
- cellular response to transforming growth factor beta stimulus [ISO]
- establishment of endothelial barrier [IDA]
- metabolic process [ISO]
- monocyte differentiation [ISO]
- negative regulation of cAMP biosynthetic process [IMP, ISO]
- negative regulation of protein import into nucleus, translocation [ISO, ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- negative regulation of vascular permeability [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of inflammatory response [ISO, ISS]
- positive regulation of vascular permeability [ISO, ISS]
- protein targeting to mitochondrion [IMP]
- regulation of cGMP metabolic process [ISO]
Gene Ontology Molecular Function- GAF domain binding [ISO]
- TPR domain binding [ISO]
- cAMP binding [IDA, ISO]
- cGMP binding [IDA, ISO]
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [IDA, ISO]
- cyclic-nucleotide phosphodiesterase activity [ISO, ISS]
- drug binding [ISO, ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
- GAF domain binding [ISO]
- TPR domain binding [ISO]
- cAMP binding [IDA, ISO]
- cGMP binding [IDA, ISO]
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [IDA, ISO]
- cyclic-nucleotide phosphodiesterase activity [ISO, ISS]
- drug binding [ISO, ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- axon [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO, ISS]
- dendrite [ISO]
- endoplasmic reticulum [ISO, ISS]
- intracellular [ISO]
- membrane raft [IDA]
- mitochondrial matrix [IDA]
- nucleus [ISO, ISS]
- perinuclear region of cytoplasm [ISO, ISS]
- plasma membrane [ISO, ISS]
- presynaptic membrane [ISO, ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.
Programmed degradation of mitochondria by mitophagy, an essential process to maintain mitochondrial homeostasis, is not completely understood. Here we uncover a regulatory process that controls mitophagy and involves the cAMP-degrading enzyme phosphodiesterase 2A2 (PDE2A2). We find that PDE2A2 is part of a mitochondrial signalosome at the mitochondrial inner membrane where it interacts with the mitochondrial contact site and organizing system ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID