BAIT

ELK3

ERP, NET, SAP2

ELK3, ETS-domain protein (SRF accessory protein 2)

GO Process (6)

GO Function (7)

GO Component (4)

Gene Ontology Biological Process

cell differentiation [IBA]

negative regulation of transcription, DNA-templated [IDA]

positive regulation of transcription from RNA polymerase II promoter [IDA]

regulation of transcription from RNA polymerase II promoter [IBA]

signal transduction [TAS]

transcription from RNA polymerase II promoter [IBA]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
protein binding [IPI]
purine-rich negative regulatory element binding [IDA]
sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
sequence-specific DNA binding transcription factor activity [NAS]
transcription corepressor activity [IDA]

Gene Ontology Cellular Component

intracellular membrane-bounded organelle [IDA]

mitochondrion [IDA]

nucleoplasm [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

CTBP1

BARS

C-terminal binding protein 1

GO Process (11)

GO Function (7)

GO Component (3)

Gene Ontology Molecular Function

NAD binding [ISS]
RNA polymerase II transcription corepressor activity [IDA]
protein C-terminus binding [TAS]
protein binding [IPI]
protein domain specific binding [IDA, IPI]
repressing transcription factor binding [IPI]
transcription factor binding [IPI]

Gene Ontology Cellular Component

nucleoplasm [IDA]

nucleus [IDA, ISS]

transcriptional repressor complex [IDA, ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Human transcription factor protein interaction networks

Goos H, Kinnunen M, Salokas K, Tan Z, Liu X, Yadav L, Zhang Q, Wei G-H, Varjosalo M

Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]

Nature Communications Feb. 09, 2022; (); [Pubmed: 35140242]

Throughput

High Throughput

Additional Notes

BioID

Curated By

BioGRID