BAIT
GATA2
DCML, IMD21, MONOMAC, NFE1B
GATA binding protein 2
GO Process (10)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- blood coagulation [TAS]
- eosinophil fate commitment [IDA]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fat cell proliferation [IMP]
- negative regulation of neural precursor cell proliferation [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of phagocytosis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
Homo sapiens
PREY
PIAS1
DDXBP1, GBP, GU/RH-II, ZMIZ3
protein inhibitor of activated STAT, 1
GO Process (10)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- androgen receptor signaling pathway [NAS]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription, DNA-templated [NAS]
- protein sumoylation [ISS]
- regulation of cell proliferation [ISS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Human transcription factor protein interaction networks
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]
Nature Communications Feb. 09, 2022; (); [Pubmed: 35140242]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID