BAIT
GLI2
CJS, HPE9, PHS2, THP1, THP2
GLI family zinc finger 2
GO Process (35)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- axon guidance [ISS]
- branching morphogenesis of an epithelial tube [ISS]
- cell proliferation [IDA]
- cellular response to virus [IDA]
- cerebellar cortex morphogenesis [ISS]
- developmental growth [ISS]
- embryonic digestive tract development [ISS]
- epidermal cell differentiation [IDA]
- floor plate formation [ISS]
- heart development [ISS]
- hindbrain development [ISS]
- hindgut morphogenesis [ISS]
- kidney development [ISS]
- lung development [ISS]
- mammary gland development [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- neuron development [ISS]
- odontogenesis of dentin-containing tooth [ISS]
- osteoblast development [ISS]
- osteoblast differentiation [IDA]
- pattern specification process [ISS]
- pituitary gland development [ISS]
- positive regulation of DNA replication [IDA]
- positive regulation of T cell differentiation in thymus [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- proximal/distal pattern formation [ISS]
- skeletal system development [ISS]
- smoothened signaling pathway [IDA]
- smoothened signaling pathway involved in ventral spinal cord interneuron specification [ISS]
- spinal cord dorsal/ventral patterning [ISS]
- spinal cord ventral commissure morphogenesis [ISS]
- tube development [ISS]
- ventral midline development [ISS]
- ventral spinal cord development [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
UBE2I
C358B7.1, P18, UBC9, LA16c-358B7.1
ubiquitin-conjugating enzyme E2I
GO Process (8)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Human transcription factor protein interaction networks
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]
Nature Communications Feb. 09, 2022; (); [Pubmed: 35140242]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID