MCL1
Gene Ontology Biological Process
- apoptotic mitochondrial changes [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- regulation of response to DNA damage stimulus [ISO]
- response to cytokine [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIN1
Gene Ontology Biological Process
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of cell motility [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein peptidyl-prolyl isomerization [ISO]
- regulation of cell proliferation [IMP]
- regulation of cytokinesis [IMP, ISO]
- regulation of pathway-restricted SMAD protein phosphorylation [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury.
Although oligodendrocytes undergo apoptosis after spinal cord injury, molecular mechanisms responsible for their death have been unknown. We report that oligodendrocyte apoptosis is regulated oppositely by c-Jun N-terminal kinase 3 (JNK3) and protein interacting with the mitotic kinase, never in mitosis A I (Pin1), the actions of which converge on myeloid cell leukemia sequence-1 (Mcl-1). Activated after injury, JNK3 induces ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID