ADRB2
Gene Ontology Biological Process
- activation of adenylate cyclase activity [IDA]
- activation of transmembrane receptor protein tyrosine kinase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- adrenergic receptor signaling pathway [IDA]
- cell surface receptor signaling pathway [TAS]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IDA]
- endosome to lysosome transport [TAS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of protein ubiquitination [IMP]
- receptor-mediated endocytosis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARRB2
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [IDA]
- adult walking behavior [ISO]
- brain development [IEP]
- cell chemotaxis [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IMP, ISO, TAS]
- detection of temperature stimulus involved in sensory perception of pain [IMP]
- endocytosis [IDA]
- follicle-stimulating hormone signaling pathway [IDA]
- negative regulation of GTPase activity [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of interleukin-1 beta production [ISO]
- negative regulation of interleukin-12 production [ISO]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of natural killer cell mediated cytotoxicity [ISO]
- negative regulation of protein ubiquitination [IMP, ISO]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- negative regulation of smooth muscle cell apoptotic process [IMP]
- negative regulation of toll-like receptor signaling pathway [ISO]
- negative regulation of tumor necrosis factor production [ISO]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of calcium ion transport [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein kinase B signaling [IMP, ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of receptor internalization [IMP, ISO]
- positive regulation of synaptic transmission, dopaminergic [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor internalization [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [IDA, ISO]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of cAMP biosynthetic process [TAS]
- regulation of cAMP catabolic process [TAS]
- regulation of protein phosphorylation [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [IDA]
- D1 dopamine receptor binding [IPI]
- G-protein coupled receptor binding [ISO, TAS]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin binding [TAS]
- enzyme binding [ISO]
- follicle-stimulating hormone receptor binding [IPI]
- mitogen-activated protein kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI]
- protein kinase B binding [ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [IPI]
- type 2A serotonin receptor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- 14-3-3 protein binding [IDA]
- D1 dopamine receptor binding [IPI]
- G-protein coupled receptor binding [ISO, TAS]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin binding [TAS]
- enzyme binding [ISO]
- follicle-stimulating hormone receptor binding [IPI]
- mitogen-activated protein kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI]
- protein kinase B binding [ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [IPI]
- type 2A serotonin receptor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
Beta-arrestin2 and its ubiquitination play crucial roles in both internalization and signaling of seven-transmembrane receptors (7TMRs). To understand the connection between ubiquitination and the endocytic and signaling functions of beta-arrestin, we generated a beta-arrestin2 mutant that is defective in ubiquitination (beta-arrestin2(0K)), by mutating all of the ubiquitin acceptor lysines to arginines and compared its properties with the wild type and ... [more]
Throughput
- Low Throughput
Additional Notes
- Adrb2 not confirmed human
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARRB2 ADRB2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 331495 |
Curated By
- BioGRID