BAIT
IRF4
LSIRF, MUM1, NF-EM5, SHEP8
interferon regulatory factor 4
GO Process (13)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- T cell activation [NAS]
- T-helper 17 cell lineage commitment [ISS]
- cytokine-mediated signaling pathway [TAS]
- defense response to protozoan [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of interleukin-10 biosynthetic process [IDA]
- positive regulation of interleukin-13 biosynthetic process [IDA]
- positive regulation of interleukin-2 biosynthetic process [IDA]
- positive regulation of interleukin-4 biosynthetic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of T-helper cell differentiation [NAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription factor binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription factor binding [NAS]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Human transcription factor protein interaction networks
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]
Nature Communications Feb. 09, 2022; (); [Pubmed: 35140242]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID