NFIB
Gene Ontology Biological Process
- Clara cell differentiation [ISS]
- Type I pneumocyte differentiation [ISS]
- Type II pneumocyte differentiation [ISS]
- anterior commissure morphogenesis [ISS]
- chondrocyte differentiation [ISS]
- commissural neuron axon guidance [ISS]
- glial cell differentiation [ISS]
- lung ciliated cell differentiation [ISS]
- negative regulation of DNA binding [IDA]
- negative regulation of epithelial cell proliferation involved in lung morphogenesis [ISS]
- negative regulation of mesenchymal cell proliferation involved in lung development [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- principal sensory nucleus of trigeminal nerve development [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription corepressor activity [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription corepressor activity [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Human transcription factor protein interaction networks
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]
Throughput
- High Throughput
Additional Notes
- BioID
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NFIB PRR12 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3771823 |
Curated By
- BioGRID