SOX9
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISS]
- Sertoli cell differentiation [ISS]
- cAMP-mediated signaling [IDA]
- cartilage condensation [ISS]
- cartilage development [ISS]
- cell fate specification [ISS]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to heparin [ISS]
- cellular response to interleukin-1 [IEP]
- cellular response to mechanical stimulus [ISS]
- cellular response to retinoic acid [IEP]
- cellular response to transforming growth factor beta stimulus [IDA]
- chondrocyte differentiation involved in endochondral bone morphogenesis [IMP]
- chondrocyte hypertrophy [ISS]
- chromatin remodeling [IDA]
- cochlea morphogenesis [ISS]
- endocardial cushion morphogenesis [ISS]
- epidermal growth factor receptor signaling pathway [ISS]
- epithelial cell proliferation involved in prostatic bud elongation [ISS]
- epithelial to mesenchymal transition [ISS]
- hair follicle development [ISS]
- heart valve development [ISS]
- heart valve morphogenesis [ISS]
- intestinal epithelial structure maintenance [ISS]
- male germ-line sex determination [ISS]
- male gonad development [IEP, IMP]
- metanephric nephron tubule formation [ISS]
- morphogenesis of a branching epithelium [ISS]
- negative regulation of apoptotic process [IMP, ISS]
- negative regulation of biomineral tissue development [ISS]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of chondrocyte differentiation [ISS]
- negative regulation of epithelial cell proliferation [ISS]
- negative regulation of immune system process [ISS]
- negative regulation of myoblast differentiation [ISS]
- negative regulation of ossification [ISS]
- negative regulation of photoreceptor cell differentiation [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- nucleosome assembly [IDA]
- otic vesicle formation [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cartilage development [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of chondrocyte differentiation [IDA, IMP]
- positive regulation of epithelial cell differentiation [ISS]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of epithelial cell proliferation [IEP, ISS]
- positive regulation of kidney development [ISS]
- positive regulation of male gonad development [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of mesenchymal stem cell differentiation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- prostate gland development [IEP]
- protein complex assembly [IDA]
- regulation of apoptotic process [ISS]
- regulation of cell cycle process [IMP]
- regulation of cell proliferation [ISS]
- regulation of cell proliferation involved in tissue homeostasis [ISS]
- renal vesicle induction [ISS]
- retina development in camera-type eye [ISS]
- retinal rod cell differentiation [ISS]
- signal transduction [ISS]
- skeletal system development [IMP]
- somatic stem cell maintenance [ISS]
- spermatogenesis [ISS]
- tissue homeostasis [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enhancer binding [IDA]
- enhancer sequence-specific DNA binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enhancer binding [IDA]
- enhancer sequence-specific DNA binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
Gene Ontology Cellular Component
UBE2I
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Human transcription factor protein interaction networks
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]
Throughput
- High Throughput
Additional Notes
- BioID
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBE2I SOX9 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1100957 |
Curated By
- BioGRID