BAIT

RB1CC1

ATG17, CC1, FIP200, PPP1R131
RB1-inducible coiled-coil 1
Autophagy Project
Homo sapiens
PREY

TMEM33

1600019D15Rik, SHINC3
transmembrane protein 33
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

Schluetermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stuehler K, Stork B

The protein kinase TBK1 is a central regulator of innate immune responses and autophagy, and ablation of either function has been linked to neuroinflammatory or degenerative diseases. Autophagy is an intracellular process that recycles old or damaged proteins and organelles. In recent years, the TBK1-dependent regulation of autophagy pathways has been characterized. However, the autophagy-dependent regulation of TBK1 activity awaits ... [more]

Sci Rep Dec. 05, 2020; 11(1);13863 [Pubmed: 34226595]

Throughput

  • Low Throughput

Curated By

  • BioGRID