CRD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GSH1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Loss of the mitochondrial lipid cardiolipin leads to decreased glutathione synthesis.
Previous studies demonstrated that loss of CL in the yeast mutant crd1? leads to perturbation of mitochondrial iron?sulfur (FeS) cluster biogenesis, resulting in decreased activity of mitochondrial and cytosolic Fe-S-requiring enzymes, including aconitase and sulfite reductase. In the current study, we show that crd1? cells exhibit decreased levels of glutamate and cysteine and are deficient in the essential antioxidant, glutathione, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GSH1 CRD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1043 | BioGRID | 539099 | |
CRD1 GSH1 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.135 | BioGRID | 2428684 |
Curated By
- BioGRID