BAIT
NKX2-5
CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3
NK2 homeobox 5
GO Process (37)
GO Function (11)
GO Component (3)
Gene Ontology Biological Process
- adult heart development [IMP]
- atrial cardiac muscle cell development [ISS]
- atrial septum morphogenesis [IMP]
- cardiac conduction system development [IMP]
- cardiac muscle cell differentiation [ISS]
- cardiac muscle tissue morphogenesis [IMP]
- cell differentiation [ISS]
- embryonic heart tube development [ISS]
- heart looping [ISS]
- heart morphogenesis [ISS]
- hemopoiesis [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- negative regulation of transcription, DNA-templated [ISS]
- outflow tract septum morphogenesis [IMP]
- pharyngeal system development [ISS]
- positive regulation of cardioblast differentiation [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of heart contraction [ISS]
- positive regulation of neuron differentiation [IMP]
- positive regulation of sodium ion transport [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISS]
- positive regulation of transcription initiation from RNA polymerase II promoter [ISS]
- positive regulation of transcription via serum response element binding [ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of voltage-gated calcium channel activity [ISS]
- regulation of cardiac muscle contraction [ISS]
- right ventricular cardiac muscle tissue morphogenesis [IMP]
- septum secundum development [IMP]
- spleen development [IMP, ISS]
- thyroid gland development [IMP]
- vasculogenesis [ISS]
- ventricular cardiac muscle cell development [ISS]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- serum response element binding [ISS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- serum response element binding [ISS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
TPM3
CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, TRK, hscp30, RP11-205M9.1
tropomyosin 3
GO Process (3)
GO Function (0)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Human transcription factor protein interaction networks
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]
Nature Communications Feb. 09, 2022; (); [Pubmed: 35140242]
Throughput
- High Throughput
Additional Notes
- Filtered using SAINT software tools (cutoff 0.74) and CRAPome database
Curated By
- BioGRID