HNF1B
Gene Ontology Biological Process
- endocrine pancreas development [IMP, TAS]
- genitalia development [IMP]
- kidney development [IDA, IMP]
- positive regulation of transcription initiation from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- pronephric nephron tubule development [IGI]
- pronephros development [IMP]
- regulation of pronephros size [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
SOX17
Gene Ontology Biological Process
- angiogenesis [ISS]
- cardiac cell fate determination [IMP]
- cardiogenic plate morphogenesis [ISS]
- embryonic foregut morphogenesis [ISS]
- embryonic heart tube development [ISS]
- embryonic heart tube morphogenesis [ISS]
- endocardial cell differentiation [ISS]
- endocardium formation [ISS]
- endoderm formation [IDA]
- endodermal digestive tract morphogenesis [ISS]
- heart formation [TAS]
- heart looping [ISS]
- mRNA transcription from RNA polymerase II promoter [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell growth [IMP]
- outflow tract morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein destabilization [IMP]
- protein stabilization [IMP]
- regulation of embryonic development [ISS]
- regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification [ISS]
- regulation of transcription, DNA-templated [ISS]
- renal system development [IMP]
- vasculogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Human transcription factor protein interaction networks
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID