HNF1B
Gene Ontology Biological Process
- endocrine pancreas development [IMP, TAS]
- genitalia development [IMP]
- kidney development [IDA, IMP]
- positive regulation of transcription initiation from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- pronephric nephron tubule development [IGI]
- pronephros development [IMP]
- regulation of pronephros size [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
PAX8
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- branching involved in ureteric bud morphogenesis [IEP]
- cellular response to gonadotropin stimulus [IDA]
- central nervous system development [IEP]
- inner ear morphogenesis [ISS]
- kidney development [IEP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IEP]
- mesonephros development [ISS]
- metanephric S-shaped body morphogenesis [IEP]
- metanephric comma-shaped body morphogenesis [IEP]
- metanephric distal convoluted tubule development [ISS]
- metanephric epithelium development [IEP]
- metanephric nephron tubule formation [ISS]
- negative regulation of apoptotic process involved in metanephric collecting duct development [ISS]
- negative regulation of apoptotic process involved in metanephric nephron tubule development [ISS]
- negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [ISS]
- negative regulation of mesenchymal cell apoptotic process involved in metanephros development [ISS]
- otic vesicle development [IEP]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISS]
- positive regulation of metanephric DCT cell differentiation [ISS]
- positive regulation of thyroid hormone generation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- pronephric field specification [ISS]
- pronephros development [ISS]
- regulation of apoptotic process [ISS]
- regulation of metanephric nephron tubule epithelial cell differentiation [ISS]
- regulation of thyroid-stimulating hormone secretion [IMP]
- thyroid gland development [IEP, IMP]
- thyroid-stimulating hormone signaling pathway [TAS]
- transcription, DNA-templated [IDA]
- urogenital system development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA, ISS]
- nucleus [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Human transcription factor protein interaction networks
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein-protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. By performing clustering ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID