ISL1
Gene Ontology Biological Process
- atrial septum morphogenesis [IGI]
- cardiac cell fate determination [IMP, ISO]
- cardiac muscle cell myoblast differentiation [IMP]
- cardiac right ventricle morphogenesis [IGI]
- endocardial cushion morphogenesis [IGI]
- heart development [IMP]
- heart morphogenesis [IGI]
- innervation [IMP]
- mesenchymal cell differentiation [IMP]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of inflammatory response [IMP]
- negative regulation of intracellular estrogen receptor signaling pathway [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron differentiation [IGI]
- negative regulation of protein homodimerization activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural crest cell migration [IGI]
- neuron differentiation [IGI, IMP]
- neuron fate commitment [IGI]
- neuron fate specification [IMP]
- outflow tract morphogenesis [IGI]
- outflow tract septum morphogenesis [IGI]
- pancreas development [IMP]
- peripheral nervous system neuron axonogenesis [IMP]
- peripheral nervous system neuron development [IGI]
- pharyngeal system development [IGI]
- pituitary gland development [IMP]
- positive regulation of DNA binding [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of granulocyte colony-stimulating factor production [IDA]
- positive regulation of granulocyte macrophage colony-stimulating factor production [IDA]
- positive regulation of insulin secretion [ISO]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interleukin-1 alpha production [IDA]
- positive regulation of interleukin-1 beta production [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of macrophage colony-stimulating factor production [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of gene expression [IMP]
- regulation of secondary heart field cardioblast proliferation [IMP]
- regulation of transcription, DNA-templated [ISO]
- retinal ganglion cell axon guidance [IMP]
- secondary heart field specification [ISO]
- sensory system development [IMP]
- spinal cord motor neuron cell fate specification [IGI]
- spinal cord motor neuron differentiation [IMP]
- transcription from RNA polymerase II promoter [ISO]
- trigeminal nerve development [IMP]
- ventricular cardiac muscle tissue morphogenesis [IGI]
- visceral motor neuron differentiation [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription coactivator activity [IDA, ISO]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [ISO]
- estrogen receptor binding [ISO]
- ligand-dependent nuclear receptor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription coactivator activity [IDA, ISO]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [ISO]
- estrogen receptor binding [ISO]
- ligand-dependent nuclear receptor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
LDB1
Gene Ontology Biological Process
- Wnt signaling pathway [IMP]
- anterior/posterior axis specification [IMP]
- cellular component assembly [IGI]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellum development [IMP]
- epithelial structure maintenance [IGI]
- gastrulation with mouth forming second [IMP]
- hair follicle development [IGI]
- head development [IGI]
- histone H3-K4 acetylation [IMP]
- negative regulation of erythrocyte differentiation [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of cell adhesion [IGI]
- positive regulation of hemoglobin biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- primitive erythrocyte differentiation [TAS]
- regulation of DNA-templated transcription, elongation [IMP]
- regulation of nucleic acid-templated transcription [IPI]
- somatic stem cell maintenance [IGI]
- transcription from RNA polymerase II promoter [IDA]
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- LIM domain binding [IDA, IPI, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- enzyme binding [IPI, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein self-association [IPI]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IDA]
- LIM domain binding [IDA, IPI, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- enzyme binding [IPI, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein self-association [IPI]
- transcription factor binding transcription factor activity [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic ?-Cell Target Genes.
Islet-1 (Isl1) is a Lin11, Isl1, Mec3 (LIM)-homeodomain transcription factor important for pancreatic islet cell development, maturation, and function, which largely requires interaction with the LIM domain-binding protein 1 (Ldb1) coregulator. In other tissues, Ldb1 and Isl1 interact with additional factors to mediate target gene transcription, yet few protein partners are known in ?-cells. Therefore, we hypothesize that Ldb1 and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LDB1 ISL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID