USP5
Gene Ontology Biological Process
Gene Ontology Molecular Function
CASP1
Gene Ontology Biological Process
- cellular response to organic substance [ISO]
- execution phase of apoptosis [IBA]
- interleukin-1 beta production [IGI]
- membrane hyperpolarization [IMP]
- memory [ISO]
- microglial cell activation [ISO]
- mitochondrial depolarization [IMP]
- myoblast fusion [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of circadian sleep/wake cycle, non-REM sleep [ISO]
- positive regulation of cytokine secretion [IMP, ISO]
- positive regulation of interleukin-1 alpha secretion [IMP]
- positive regulation of interleukin-1 beta secretion [IMP, ISO]
- programmed necrotic cell death [IDA]
- protein processing [IDA, IMP]
- proteolysis [IBA, ISO]
- pyroptosis [IMP]
- regulation of autophagy [IMP]
- regulation of inflammatory response [IMP]
- response to ATP [IMP]
- response to bacterium [IMP]
- response to drug [ISO]
- response to hypoxia [IMP, ISO]
- response to lipopolysaccharide [IDA, ISO]
- response to organic cyclic compound [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3.
3-MA: 3-methyladenine; AIM2: absent in melanoma 2; ATG5: autophagy related 5; BafA1: bafilomycin A1; CASP1: caspase 1; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; DUBs: deubiquitinases; IL1B/IL-1?: interleukin 1 beta; LAMP1: lysosomal associated membrane protein 1; LPS: lipopolysaccharide; MARCHF7/MARCH7: membrane associated RING-CH-type finger 7; NFKB/NF-?B: nuclear factor kappa B; Nig.: nigericin; NLRC4: NLR family CARD domain containing 4; NLRP3: NLR family ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID