WWP1
Gene Ontology Biological Process
- central nervous system development [NAS]
- ion transmembrane transport [TAS]
- negative regulation of transcription, DNA-templated [ISS]
- protein ubiquitination [TAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- signal transduction [NAS]
- transmembrane transport [TAS]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTCH1
Gene Ontology Biological Process
- brain development [ISS]
- cellular response to cholesterol [IMP, ISS]
- dorsal/ventral pattern formation [ISS]
- embryonic limb morphogenesis [ISS]
- limb morphogenesis [IMP]
- negative regulation of multicellular organism growth [ISS]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of smoothened signaling pathway [ISS, TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural plate axis specification [ISS]
- neural tube patterning [IMP]
- organ morphogenesis [ISS]
- pharyngeal system development [IMP]
- positive regulation of cholesterol efflux [IDA]
- protein processing [ISS]
- protein targeting to plasma membrane [IDA]
- regulation of smoothened signaling pathway [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened.
The Hedgehog pathway, critical to vertebrate development, is organized in primary cilia. Activation of signaling causes the Hedgehog receptor Ptch1 to exit cilia, allowing a second receptor, Smo, to accumulate in cilia and activate the downstream steps of the pathway. Mechanisms regulating the dynamics of these receptors are unknown, but the ubiquitination of Smo regulates its interaction with the intraflagellar ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTCH1 WWP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID