BAIT
SIK2
LOH11CR1I, QIK, SNF1LK2
salt-inducible kinase 2
GO Process (4)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
GNAI3
87U6, ARCND1, RP5-1160K1.2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GO Process (8)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- cell division [IDA]
- negative regulation of adenylate cyclase activity [TAS]
- platelet activation [TAS]
- synaptic transmission [TAS]
- transport [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SIK2 orchestrates actin-dependent host response upon Salmonella infection.
Salmonella is an intracellular pathogen of a substantial global health concern. In order to identify key players involved in Salmonella infection, we performed a global host phosphoproteome analysis subsequent to bacterial infection. Thereby, we identified the kinase SIK2 as a central component of the host defense machinery upon Salmonella infection. SIK2 depletion favors the escape of bacteria from the Salmonella-containing ... [more]
Proc Natl Acad Sci U S A Dec. 11, 2020; 118(19); [Pubmed: 33947818]
Throughput
- High Throughput
Curated By
- BioGRID