BAIT

SIK2

LOH11CR1I, QIK, SNF1LK2
salt-inducible kinase 2
UPS Project
Homo sapiens
PREY

TPM2

AMCD1, DA1, DA2B, HEL-S-273, NEM4, TMSB, RP11-112J3.4
tropomyosin 2 (beta)
GO Process (3)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

SIK2 orchestrates actin-dependent host response upon Salmonella infection.

Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Muench C, Rajalingam K, Randow F, Choudhary C, Dikic I

Salmonella is an intracellular pathogen of a substantial global health concern. In order to identify key players involved in Salmonella infection, we performed a global host phosphoproteome analysis subsequent to bacterial infection. Thereby, we identified the kinase SIK2 as a central component of the host defense machinery upon Salmonella infection. SIK2 depletion favors the escape of bacteria from the Salmonella-containing ... [more]

Proc Natl Acad Sci U S A Dec. 11, 2020; 118(19); [Pubmed: 33947818]

Throughput

  • High Throughput

Curated By

  • BioGRID