BAIT
ATRX
4833408C14Rik, AI447451, ATR2, DXHXS6677E, HP1-BP38, Hp1bp2, Hp1bp38, MRXS3, RAD54L, Rad54, XH2, Xnp, ZNF-HX, RP23-170G19.5
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
GO Process (15)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA damage response, signal transduction by p53 class mediator [IMP]
- DNA replication-independent nucleosome assembly [ISO]
- Sertoli cell development [IMP]
- cellular response to hydroxyurea [IMP]
- chromatin remodeling [ISO]
- forebrain development [IMP]
- negative regulation of telomeric RNA transcription from RNA pol II promoter [IMP]
- nucleosome assembly [ISO]
- positive regulation of nuclear cell cycle DNA replication [IMP]
- positive regulation of telomere maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- replication fork processing [IMP]
- seminiferous tubule development [IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MCM4
19G, AI325074, AU045576, Cdc21, Mcmd4, mKIAA4003, mcdc21
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
GO Process (1)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.
ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures. While several studies demonstrate that loss of ATRX sensitizes cells to chemical stabilizers of G4 structures, the molecular function of ATRX at G4 regions during replication remains unknown. Here, we demonstrate that ATRX associates with a ... [more]
Nat Commun Dec. 23, 2020; 12(1);3887 [Pubmed: 34162889]
Throughput
- Low Throughput
Additional Notes
- Proximity Ligation Assay
Curated By
- BioGRID