ATRX
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA damage response, signal transduction by p53 class mediator [ISS]
- DNA duplex unwinding [TAS]
- DNA methylation [TAS]
- DNA recombination [TAS]
- DNA replication-independent nucleosome assembly [IMP]
- cellular response to hydroxyurea [ISS]
- chromatin remodeling [IDA]
- negative regulation of telomeric RNA transcription from RNA pol II promoter [ISS]
- nucleosome assembly [IDA]
- positive regulation of nuclear cell cycle DNA replication [ISS]
- positive regulation of telomere maintenance [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [TAS]
- replication fork processing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DAXX
Gene Ontology Biological Process
- PML body organization [ISO]
- androgen receptor signaling pathway [ISO]
- apoptotic signaling pathway [IGI]
- chromatin remodeling [ISO]
- mitotic cytokinesis [IMP]
- negative regulation of myotube differentiation [ISO]
- negative regulation of nucleic acid-templated transcription [TAS]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- nucleosome assembly [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA, IGI]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of protein ubiquitination [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- enzyme binding [ISO]
- histone binding [IDA, ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase activator activity [ISO]
- protein kinase binding [ISO]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO, TAS]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- androgen receptor binding [ISO]
- enzyme binding [ISO]
- histone binding [IDA, ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase activator activity [ISO]
- protein kinase binding [ISO]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO, TAS]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.
ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures. While several studies demonstrate that loss of ATRX sensitizes cells to chemical stabilizers of G4 structures, the molecular function of ATRX at G4 regions during replication remains unknown. Here, we demonstrate that ATRX associates with a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID