An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.

Publication

Cysteine residues 87 and 320 in the amino terminal domain of NMDA receptor GluN2A govern its homodimerization but do not influence GluN2A/GluN1 heteromeric assembly.

Zhang XM, Lv XY, Tang Y, Zhu LJ, Luo JH

N-Methyl-D-aspartate receptors (NMDARs) play a central role in various physiological and pathological processes in the central nervous system. And they are commonly composed of four subunits, two GluN1 subunits and two GluN2 or GluN3 subunits. The different subunit compositions make NMDARs a heterogeneous population with distinct electrophysiological and pharmacological properties and thus with different abilities to conduct neuronal activities. The ... [more]

Neurosci Bull Dec. 01, 2013; 29(6);671-84 [Pubmed: 23604598]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
GRIN2A GRIN2A	FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.	Qiu S (2005)	Low	-	BioGRID	-
GRIN2A GRIN2A	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Zhang XM (2013)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

GRIN2A

Gene Ontology Biological Process

Gene Ontology Molecular Function

N-methyl-D-aspartate selective glutamate receptor activity [IBA]extracellular-glutamate-gated ion channel activity [IBA]protein binding [IPI]zinc ion binding [ISS]

Gene Ontology Cellular Component