BAIT
PDE2A
CGS-PDE, PDE2A1, PED2A4, cGSPDE
phosphodiesterase 2A, cGMP-stimulated
GO Process (22)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cAMP catabolic process [IDA, IMP]
- cAMP-mediated signaling [IMP]
- cGMP catabolic process [IDA]
- cGMP-mediated signaling [IMP]
- calcium ion transmembrane transport [TAS]
- cellular response to cGMP [IDA]
- cellular response to drug [IEP, IMP]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to macrophage colony-stimulating factor stimulus [IDA]
- cellular response to mechanical stimulus [ISS]
- cellular response to transforming growth factor beta stimulus [IEP]
- establishment of endothelial barrier [ISS]
- metabolic process [IDA]
- monocyte differentiation [IEP]
- negative regulation of cAMP biosynthetic process [ISS]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of vascular permeability [IMP]
- positive regulation of inflammatory response [ISS]
- positive regulation of vascular permeability [IMP]
- protein targeting to mitochondrion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLSCR1
MMTRA1B
phospholipid scramblase 1
GO Process (14)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- acute-phase response [ISS]
- apoptotic process [IDA]
- defense response to virus [IMP]
- negative regulation of viral genome replication [IMP]
- phosphatidylserine biosynthetic process [ISS]
- phospholipid scrambling [IDA]
- platelet activation [NAS]
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of innate immune response [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [ISS]
- regulation of mast cell activation [ISS]
- response to interferon-beta [IMP]
Gene Ontology Molecular Function- CD4 receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SH3 domain binding [IDA]
- calcium ion binding [IDA, NAS]
- enzyme binding [IPI]
- epidermal growth factor receptor binding [IPI]
- phospholipid scramblase activity [IDA]
- protein binding [IPI]
- CD4 receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SH3 domain binding [IDA]
- calcium ion binding [IDA, NAS]
- enzyme binding [IPI]
- epidermal growth factor receptor binding [IPI]
- phospholipid scramblase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.
Programmed degradation of mitochondria by mitophagy, an essential process to maintain mitochondrial homeostasis, is not completely understood. Here we uncover a regulatory process that controls mitophagy and involves the cAMP-degrading enzyme phosphodiesterase 2A2 (PDE2A2). We find that PDE2A2 is part of a mitochondrial signalosome at the mitochondrial inner membrane where it interacts with the mitochondrial contact site and organizing system ... [more]
Commun Biol Dec. 21, 2019; 3(1);596 [Pubmed: 33087821]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID