BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ANKRD17
4933425K22Rik, A130069E23Rik, A930008M01, AA407558, AA516750, AU040470, Foe, Gtar, Mask, mKIAA0697
ankyrin repeat domain 17
GO Process (11)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- blood vessel maturation [IMP]
- defense response to bacterium [ISO]
- endoderm development [TAS]
- innate immune response [ISO]
- negative regulation of smooth muscle cell differentiation [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of MDA-5 signaling pathway [ISO]
- positive regulation of RIG-I signaling pathway [ISO]
- positive regulation of cell cycle [ISO]
- regulation of DNA replication [ISO]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID