BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ATP2A2
9530097L16Rik, D5Wsu150e, SERCA2, SERCA2B, mKIAA4195
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
GO Process (22)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- ER-nucleus signaling pathway [IMP]
- T-tubule organization [IMP]
- calcium ion import into sarcoplasmic reticulum [ISO]
- calcium ion transmembrane transport [IDA, ISO]
- calcium ion transport [ISO]
- calcium ion transport from cytosol to endoplasmic reticulum [ISO]
- cellular calcium ion homeostasis [IDA, IGI, IMP, ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- negative regulation of heart contraction [IGI]
- organelle organization [IMP]
- positive regulation of endoplasmic reticulum calcium ion concentration [ISO]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [IMP]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [ISO]
- regulation of cardiac muscle cell membrane potential [ISO]
- regulation of cardiac muscle contraction by calcium ion signaling [ISO]
- regulation of muscle contraction [TAS]
- regulation of the force of heart contraction [IGI]
- relaxation of cardiac muscle [ISO]
- response to peptide hormone [ISO]
- sarcoplasmic reticulum calcium ion transport [IMP, ISO]
- transition between fast and slow fiber [IDA]
Gene Ontology Molecular Function- ATP binding [ISO]
- S100 protein binding [ISO]
- calcium ion binding [ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [ISO]
- enzyme binding [IPI, ISO]
- lutropin-choriogonadotropic hormone receptor binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- ATP binding [ISO]
- S100 protein binding [ISO]
- calcium ion binding [ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [ISO]
- enzyme binding [IPI, ISO]
- lutropin-choriogonadotropic hormone receptor binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [ISO]
- cell [IGI]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- intercalated disc [ISO]
- longitudinal sarcoplasmic reticulum [ISO]
- membrane [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
- ribbon synapse [IDA]
- sarcoplasmic reticulum [IDA, ISO, TAS]
- vesicle membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID