BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ATP5B
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
GO Process (12)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- ADP biosynthetic process [ISO]
- ATP biosynthetic process [ISO]
- ATP catabolic process [ISO]
- ATP metabolic process [ISO]
- angiogenesis [ISO]
- hydrogen ion transmembrane transport [ISO]
- lipid metabolic process [IMP]
- negative regulation of cell adhesion involved in substrate-bound cell migration [IMP]
- osteoblast differentiation [ISO]
- proton transport [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of intracellular pH [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- mitochondrial inner membrane [IDA, ISO]
- mitochondrial membrane [ISO]
- mitochondrial nucleoid [ISO]
- mitochondrial proton-transporting ATP synthase complex [ISO]
- mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nucleus [ISO]
- plasma membrane [ISO]
- proton-transporting ATP synthase complex, catalytic core F(1) [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID