BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
AFG3L2
2310036I02Rik, AW260507, Emv66, par
AFG3-like AAA ATPase 2
GO Process (12)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- axonogenesis [IMP]
- cristae formation [IGI]
- death [IMP]
- mitochondrial fusion [IGI]
- mitochondrial protein processing [IGI]
- mitochondrion organization [IGI]
- muscle fiber development [IMP]
- myelination [IMP]
- nerve development [IMP]
- neuromuscular junction development [IMP]
- regulation of multicellular organism growth [IMP]
- righting reflex [IMP]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID