BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TLR3
AI957183
toll-like receptor 3
GO Process (32)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISO]
- cellular response to exogenous dsRNA [ISO]
- defense response [IMP]
- defense response to virus [IGI, TAS]
- extrinsic apoptotic signaling pathway [ISO]
- innate immune response [TAS]
- microglial cell activation [ISO]
- microglial cell activation involved in immune response [ISO]
- necroptotic signaling pathway [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IGI, IMP]
- positive regulation of JNK cascade [IDA]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of chemokine biosynthetic process [IMP]
- positive regulation of chemokine production [ISO]
- positive regulation of interferon-alpha biosynthetic process [ISO]
- positive regulation of interferon-beta biosynthetic process [ISO, ISS]
- positive regulation of interferon-beta production [IDA]
- positive regulation of interferon-gamma biosynthetic process [ISO]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-6 production [IDA, IMP, ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of toll-like receptor signaling pathway [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of tumor necrosis factor production [IDA, IMP]
- positive regulation of type I interferon production [IDA]
- positive regulation of type III interferon production [IDA]
- response to dsRNA [ISO]
- response to exogenous dsRNA [IMP, ISO]
- response to virus [IMP]
- toll-like receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID