BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CDC7
AI597260, Cdc7l1, muCdc7
cell division cycle 7 (S. cerevisiae)
GO Process (10)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- DNA replication initiation [IBA]
- cell cycle phase transition [ISO]
- double-strand break repair via break-induced replication [IBA]
- peptidyl-serine phosphorylation [IBA]
- phagocytosis [IBA]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of nuclear cell cycle DNA replication [ISO]
- protein phosphorylation [ISO]
- regulation of cell shape [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID