BAIT

KCNA3

Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
Mus musculus
PREY

VPS13A

4930425F11, 4930516E05Rik, 4930543C13Rik, 9930023P20, Chac, Chorein, D330038K10Rik, mKIAA0986
vacuolar protein sorting 13A (yeast)
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

Cidad P, Alonso E, Arevalo-Martinez M, Calvo E, de la Fuente MA, Perez-Garcia MT, Lopez-Lopez JR

The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+  channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]

J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]

Throughput

  • High Throughput

Additional Notes

  • Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.

Curated By

  • BioGRID