BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RYR1
AI528790, RYR-1, Ryr, skrr
ryanodine receptor 1, skeletal muscle
GO Process (16)
GO Function (6)
GO Component (17)
Gene Ontology Biological Process
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IDA, ISO]
- cellular response to caffeine [IMP]
- cytosolic calcium ion homeostasis [ISO]
- muscle contraction [IDA, IMP]
- ossification involved in bone maturation [IMP]
- outflow tract morphogenesis [IMP]
- regulation of ion transmembrane transport [IDA]
- regulation of muscle contraction [TAS]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP]
- response to caffeine [ISO]
- response to hypoxia [ISO]
- sarcoplasmic reticulum calcium ion transport [ISO]
- skeletal muscle fiber development [IMP]
- skin development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- I band [ISO]
- T-tubule [IDA]
- cell [IMP]
- cell cortex [ISO]
- cytoplasm [ISO]
- cytosol [IMP]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- intracellular [IMP]
- junctional membrane complex [IDA]
- membrane [IDA]
- plasma membrane [ISO]
- protein complex [IDA]
- sarcolemma [ISO]
- sarcoplasmic reticulum [IDA, ISO]
- sarcoplasmic reticulum membrane [IDA, ISO]
- smooth endoplasmic reticulum [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID