BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAF1
6430402F14Rik, AA990557, BB129353, Craf1, D830050J10Rik, Raf-1, c-Raf, v-Raf
v-raf-leukemia viral oncogene 1
GO Process (16)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- activation of MAPKK activity [ISO]
- cell differentiation [IGI]
- death-inducing signaling complex assembly [IMP]
- intermediate filament cytoskeleton organization [IMP]
- intracellular signal transduction [TAS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- negative regulation of protein complex assembly [ISO]
- neurotrophin TRK receptor signaling pathway [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- protein phosphorylation [ISO, TAS]
- response to hypoxia [ISO]
- response to muscle stretch [IMP]
- somatic stem cell maintenance [IGI]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase kinase kinase activity [ISO]
- Ras GTPase binding [IPI]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [ISO]
- ATP binding [ISO]
- MAP kinase kinase kinase activity [ISO]
- Ras GTPase binding [IPI]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID