BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LRRK2
4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46
leucine-rich repeat kinase 2
GO Process (48)
GO Function (21)
GO Component (29)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- MAPK cascade [ISO]
- activation of MAPK activity [ISO]
- activation of MAPKK activity [ISO]
- cellular response to dopamine [ISO]
- cellular response to manganese ion [ISO]
- cellular response to oxidative stress [ISO]
- determination of adult lifespan [ISO]
- endocytosis [ISO]
- exploration behavior [ISO]
- intracellular distribution of mitochondria [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of peroxidase activity [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein processing [ISO]
- negative regulation of protein targeting to mitochondrion [ISO]
- negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [ISO]
- neuromuscular junction development [ISO]
- neuron death [ISO]
- neuron projection morphogenesis [ISO]
- olfactory bulb development [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of autophagy [IMP, ISO]
- positive regulation of dopamine receptor signaling pathway [ISO]
- positive regulation of programmed cell death [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein autoubiquitination [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein autophosphorylation [ISA, ISO]
- protein phosphorylation [ISA, ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of branching morphogenesis of a nerve [ISO]
- regulation of dendritic spine morphogenesis [ISO]
- regulation of kidney size [IMP]
- regulation of locomotion [ISO]
- regulation of membrane potential [ISO]
- regulation of mitochondrial depolarization [ISO]
- regulation of neuroblast proliferation [ISO]
- regulation of neuron death [ISO]
- regulation of neuron maturation [ISO]
- regulation of synaptic vesicle exocytosis [ISO]
- response to oxidative stress [ISO]
- tangential migration from the subventricular zone to the olfactory bulb [ISO]
Gene Ontology Molecular Function- GTP binding [ISA, ISO]
- GTP-dependent protein kinase activity [ISA, ISO]
- GTPase activator activity [ISO]
- GTPase activity [ISO]
- MAP kinase kinase activity [ISO]
- Rho GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [ISO]
- clathrin binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- kinase activity [ISO]
- peroxidase inhibitor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- syntaxin-1 binding [ISO]
- tubulin binding [ISO]
- GTP binding [ISA, ISO]
- GTP-dependent protein kinase activity [ISA, ISO]
- GTPase activator activity [ISO]
- GTPase activity [ISO]
- MAP kinase kinase activity [ISO]
- Rho GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [ISO]
- clathrin binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- kinase activity [ISO]
- peroxidase inhibitor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- syntaxin-1 binding [ISO]
- tubulin binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- axon [ISO]
- cytoplasm [ISO]
- cytoplasmic side of mitochondrial outer membrane [ISO]
- cytoplasmic vesicle [IDA]
- cytosol [ISO]
- dendrite [ISO]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- inclusion body [ISO]
- intracellular membrane-bounded organelle [ISO]
- lysosome [IDA]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial inner membrane [IDA]
- mitochondrial matrix [IDA]
- mitochondrial membrane [ISO]
- mitochondrial outer membrane [IDA]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- perikaryon [ISO]
- plasma membrane [IDA]
- synapse [IDA]
- synaptic vesicle [IDA]
- trans-Golgi network [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID