BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CACNA1B
AW050276, AW060892, AW822256, Cav2.2, Cchn1a, alpha(1B), RP23-264D16.5
calcium channel, voltage-dependent, N type, alpha 1B subunit
GO Process (15)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IBA, IMP]
- calcium ion transport [IMP, ISO]
- locomotory behavior [IMP]
- membrane depolarization during action potential [IBA]
- neurotransmitter secretion [IMP]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of blood pressure [IMP]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [IMP]
- regulation of ion transmembrane transport [IMP]
- response to organic cyclic compound [ISO]
- response to pain [IMP]
- response to testosterone [ISO]
- sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID