BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KMT2A
6430520K01, ALL-1, All1, Cxxc7, HRX, HTRX1, Mll, Mll1, mKIAA4050
lysine (K)-specific methyltransferase 2A
GO Process (13)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- DNA methylation [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- embryonic hemopoiesis [IMP]
- histone H3-K4 methylation [ISO]
- histone H3-K4 trimethylation [ISO]
- histone H4-K16 acetylation [ISO]
- negative regulation of cell proliferation [IMP]
- positive regulation of cellular response to drug [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transporter activity [ISO]
- protein complex assembly [ISO]
- regulation of histone H3-K4 methylation [IMP]
Gene Ontology Molecular Function- chromatin binding [IDA]
- histone methyltransferase activity (H3-K4 specific) [ISO]
- identical protein binding [ISO]
- lysine-acetylated histone binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transcription regulatory region DNA binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [ISO]
- chromatin binding [IDA]
- histone methyltransferase activity (H3-K4 specific) [ISO]
- identical protein binding [ISO]
- lysine-acetylated histone binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transcription regulatory region DNA binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID