BAIT

KCNA3

Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
Mus musculus
PREY

DOCK10

9330153B10Rik, A630054M16Rik, Jr4, Jr5, R75174, ZIZ3, Zizimin3, mKIAA0694
dedicator of cytokinesis 10
GO Process (2)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

Cidad P, Alonso E, Arevalo-Martinez M, Calvo E, de la Fuente MA, Perez-Garcia MT, Lopez-Lopez JR

The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+  channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]

J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]

Throughput

  • High Throughput

Additional Notes

  • Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.

Curated By

  • BioGRID