BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NRIP1
6030458L20Rik, 8430438I05Rik, 9630050P12, AA959574, AW456757, RIP140
nuclear receptor interacting protein 1
GO Process (7)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- circadian regulation of gene expression [IMP, ISO]
- lipid storage [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- ovarian follicle rupture [IMP]
- ovulation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- core promoter sequence-specific DNA binding [ISO]
- estrogen receptor binding [ISO]
- glucocorticoid receptor binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- receptor binding [IPI]
- retinoic acid receptor binding [IPI]
- retinoid X receptor binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [IDA, ISO]
- core promoter sequence-specific DNA binding [ISO]
- estrogen receptor binding [ISO]
- glucocorticoid receptor binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- receptor binding [IPI]
- retinoic acid receptor binding [IPI]
- retinoid X receptor binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID