BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SCRIB
AI118201, CRIB, Crc, SCRIB1, Scrb1, mKIAA0147, vartul
scribbled homolog (Drosophila)
GO Process (22)
GO Function (1)
GO Component (13)
Gene Ontology Biological Process
- activation of Rac GTPase activity [ISO]
- apoptotic process involved in morphogenesis [ISO]
- astrocyte cell migration [ISO]
- asymmetric protein localization [IMP]
- auditory receptor cell morphogenesis [IGI]
- auditory receptor cell stereocilium organization [IGI]
- cell migration [IMP, ISO]
- cell proliferation [ISO]
- cochlear nucleus development [IGI]
- establishment of apical/basal cell polarity [ISO]
- mammary gland duct morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of mitotic cell cycle [ISO]
- neural tube closure [IMP, ISO]
- positive chemotaxis [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of receptor recycling [ISO]
- protein localization to adherens junction [ISO]
- single organismal cell-cell adhesion [ISO]
- synaptic vesicle endocytosis [IMP]
- synaptic vesicle targeting [IMP]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [ISO]
- basolateral plasma membrane [IDA]
- cell [IMP]
- cell leading edge [ISO]
- cell-cell adherens junction [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- myelin sheath abaxonal region [IDA]
- nucleoplasm [ISO]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID