BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
IFT20
0610009H04Rik, AU015496, RP23-399H5.8
intraflagellar transport 20
GO Process (16)
GO Function (2)
GO Component (16)
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IMP]
- centrosome localization [IMP]
- cilium assembly [IMP, ISO]
- intraciliary transport [IBA, IC, IMP]
- kidney development [IMP]
- neural precursor cell proliferation [IMP]
- neurogenesis [IMP]
- opsin transport [IMP]
- photoreceptor cell outer segment organization [IMP]
- protein localization to Golgi apparatus [IBA, ISO]
- protein localization to cilium [IMP, ISO]
- regulation of autophagic vacuole assembly [IMP]
- regulation of canonical Wnt signaling pathway [IMP]
- regulation of cilium assembly [IMP]
- smoothened signaling pathway [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell [IBA]
- centriole [IDA]
- centrosome [IDA, ISO]
- ciliary basal body [IDA]
- ciliary base [IDA]
- cilium [IBA, IDA]
- dendrite terminus [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- intraciliary transport particle B [IDA]
- microtubule cytoskeleton [ISO]
- motile cilium [IDA]
- photoreceptor connecting cilium [IDA]
- photoreceptor outer segment [IDA]
- primary cilium [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID