BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PFKM
AI131669, ATP-PFK, PFK-A, PFK-M, Pfk-4, Pfk4, Pfka, Pfkx
phosphofructokinase, muscle
GO Process (10)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- carbohydrate phosphorylation [IMP, ISO]
- fructose 1,6-bisphosphate metabolic process [ISO]
- fructose 6-phosphate metabolic process [ISO]
- glucose homeostasis [IMP]
- glycolytic process [IDA, IMP, ISO, ISS]
- glycolytic process through fructose-6-phosphate [IC]
- muscle cell cellular homeostasis [ISO]
- positive regulation of insulin secretion [IMP]
- protein homotetramerization [ISO]
- protein oligomerization [ISO]
Gene Ontology Molecular Function- 6-phosphofructokinase activity [IDA, IMP, ISO, ISS]
- AMP binding [ISO]
- ATP binding [ISO]
- carbohydrate binding [ISO]
- fructose binding [ISO]
- fructose-6-phosphate binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- phosphofructokinase activity [IDA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- 6-phosphofructokinase activity [IDA, IMP, ISO, ISS]
- AMP binding [ISO]
- ATP binding [ISO]
- carbohydrate binding [ISO]
- fructose binding [ISO]
- fructose-6-phosphate binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- phosphofructokinase activity [IDA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID