BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DNM1L
6330417M19Rik, AI450666, Dlp1, Dnmlp1, Drp1, python
dynamin 1-like
GO Process (19)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- dynamin polymerization involved in mitochondrial fission [ISO]
- membrane fission involved in mitochondrial fission [ISO]
- membrane fusion [ISO]
- mitochondrial fission [IMP, ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrion morphogenesis [ISO]
- necroptotic process [IMP, ISO]
- peroxisome fission [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- protein homotetramerization [ISO]
- protein localization to mitochondrion [IMP]
- regulation of mitochondrion organization [ISO]
- regulation of peroxisome organization [ISO]
- regulation of protein oligomerization [ISO]
- release of cytochrome c from mitochondria [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID