BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MSH2
AI788990
mutS homolog 2 (E. coli)
GO Process (30)
GO Function (27)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IMP, ISO]
- B cell differentiation [IMP]
- B cell mediated immunity [IMP]
- DNA repair [IMP, ISO]
- cell cycle arrest [IMP]
- cellular response to DNA damage stimulus [IMP]
- determination of adult lifespan [IMP]
- double-strand break repair [IMP]
- germ cell development [IMP]
- in utero embryonic development [IGI]
- intra-S DNA damage checkpoint [IGI]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA, IGI]
- isotype switching [IMP]
- maintenance of DNA repeat elements [IBA, ISO]
- male gonad development [IMP]
- meiotic gene conversion [IBA]
- meiotic mismatch repair [IBA]
- mismatch repair [IDA, IGI, IMP, ISO]
- negative regulation of DNA recombination [IMP, ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of reciprocal meiotic recombination [IBA]
- oxidative phosphorylation [IMP]
- positive regulation of helicase activity [ISO]
- postreplication repair [IMP, ISO]
- response to UV-B [IMP]
- response to X-ray [IMP]
- somatic hypermutation of immunoglobulin genes [IGI, IMP]
- somatic recombination of immunoglobulin gene segments [IGI, IMP]
- somatic recombination of immunoglobulin genes involved in immune response [IGI]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [IMP, ISO]
- DNA binding [IMP, ISO]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [ISO]
- Y-form DNA binding [IBA]
- centromeric DNA binding [IDA]
- damaged DNA binding [IMP]
- dinucleotide insertion or deletion binding [ISO]
- dinucleotide repeat insertion binding [ISO]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- four-way junction DNA binding [IBA, ISO]
- guanine/thymine mispair binding [IDA, ISO]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [ISO]
- mismatched DNA binding [IMP, ISO]
- oxidized purine DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- single base insertion or deletion binding [IBA]
- single guanine insertion binding [ISO]
- single thymine insertion binding [ISO]
- single-stranded DNA binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [IMP, ISO]
- DNA binding [IMP, ISO]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [ISO]
- Y-form DNA binding [IBA]
- centromeric DNA binding [IDA]
- damaged DNA binding [IMP]
- dinucleotide insertion or deletion binding [ISO]
- dinucleotide repeat insertion binding [ISO]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- four-way junction DNA binding [IBA, ISO]
- guanine/thymine mispair binding [IDA, ISO]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [ISO]
- mismatched DNA binding [IMP, ISO]
- oxidized purine DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- single base insertion or deletion binding [IBA]
- single guanine insertion binding [ISO]
- single thymine insertion binding [ISO]
- single-stranded DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID