BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NACA
AL022831, AL024382, Gm1878, mKIAA0363, skNAC
nascent polypeptide-associated complex alpha polypeptide
GO Process (11)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- cardiac ventricle development [IMP]
- heart trabecula morphogenesis [IMP]
- myoblast migration [IMP]
- negative regulation of striated muscle cell apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter involved in heart development [IMP]
- positive regulation of cell proliferation involved in heart morphogenesis [IMP]
- positive regulation of skeletal muscle tissue growth [IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in heart development [IMP]
- regulation of nucleic acid-templated transcription [IDA]
- regulation of skeletal muscle fiber development [IMP]
- skeletal muscle tissue regeneration [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID