BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SORL1
2900010L19Rik, AI596264, AW261561, LR11, SorLA, gp250, mSorLA
sortilin-related receptor, LDLR class A repeats-containing
GO Process (19)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- cell migration [ISO]
- negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein oligomerization [ISO]
- positive regulation of ER to Golgi vesicle-mediated transport [ISO]
- positive regulation of early endosome to recycling endosome transport [ISO]
- positive regulation of endocytic recycling [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein exit from endoplasmic reticulum [ISO]
- positive regulation of protein localization to early endosome [ISO]
- post-Golgi vesicle-mediated transport [ISO]
- protein maturation [ISO]
- protein retention in Golgi apparatus [ISO]
- protein targeting [ISO]
- protein targeting to Golgi [ISO]
- protein targeting to lysosome [ISO]
- regulation of smooth muscle cell migration [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi cisterna [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- multivesicular body [ISO]
- neuronal cell body [ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [ISO]
- recycling endosome [ISO]
- trans-Golgi network [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID