BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NCOA2
D1Ertd433e, GRIP-1, Grip1, KAT13C, NCoA-2, SRC-2, TIF2, bHLHe75
nuclear receptor coactivator 2
GO Process (10)
GO Function (18)
GO Component (10)
Gene Ontology Biological Process
- cellular response to hormone stimulus [IBA]
- intracellular receptor signaling pathway [IBA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of female receptivity [ISO]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- positive regulation of receptor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- regulation of glucose metabolic process [IMP]
- regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- DNA polymerase binding [ISO]
- PDZ domain binding [ISO]
- chromatin binding [IDA]
- estrogen receptor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-dependent nuclear receptor binding [IBA, ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA, ISO]
- nuclear hormone receptor binding [IBA, ISO]
- progesterone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- receptor binding [IDA]
- retinoic acid receptor binding [ISO]
- retinoid X receptor binding [ISO]
- thyroid hormone receptor binding [ISO]
- thyroid hormone receptor coactivator activity [IDA]
- transcription coactivator activity [IDA, IGI]
- transcription factor binding [IPI]
- DNA polymerase binding [ISO]
- PDZ domain binding [ISO]
- chromatin binding [IDA]
- estrogen receptor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-dependent nuclear receptor binding [IBA, ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA, ISO]
- nuclear hormone receptor binding [IBA, ISO]
- progesterone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- receptor binding [IDA]
- retinoic acid receptor binding [ISO]
- retinoid X receptor binding [ISO]
- thyroid hormone receptor binding [ISO]
- thyroid hormone receptor coactivator activity [IDA]
- transcription coactivator activity [IDA, IGI]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID