BAIT
KCNA3
Kca1-3, Kv1.3, Mk-3
potassium voltage-gated channel, shaker-related subfamily, member 3
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CARD11
0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1
caspase recruitment domain family, member 11
GO Process (13)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- T cell costimulation [ISO]
- positive regulation of B cell proliferation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of cytokine production [ISO]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- regulation of B cell differentiation [IMP]
- regulation of T cell differentiation [IMP]
- regulation of immune response [IMP]
- signal transduction [IDA]
- thymic T cell selection [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.
The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for ... [more]
J Cell Physiol Dec. 01, 2020; 236(6);4330-4347 [Pubmed: 33230847]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactions.
Curated By
- BioGRID