BAIT
BRD9
LAVS3040, PRO9856, UNQ3040/PRO9856
bromodomain containing 9
GO Process (0)
GO Function (2)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
EPB41L2
4.1-G, 4.1G, RP3-324N14.1
erythrocyte membrane protein band 4.1-like 2
GO Process (0)
GO Function (0)
GO Component (8)
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring of the interaction landscape, with three distinct classes of behavior for the 603 unique interactors identified. A group of proteins ... [more]
Mol. Cell Dec. 07, 2018; 73(3);621-638.e17 [Pubmed: 30554943]
Throughput
- High Throughput
Additional Notes
- BRD9 full length untreated sample
- FLAG AP-MS dataset using FLAG-tagged BRD9 bait protein (Table S2K)
- High confidence interactions have a Bayesian FDR=<1%
Curated By
- BioGRID