BAIT
SYK
Sykb
spleen tyrosine kinase
GO Process (52)
GO Function (11)
GO Component (9)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway [TAS]
- activation of JUN kinase activity [IMP]
- activation of MAPK activity [IDA, IMP]
- adaptive immune response [IBA]
- beta selection [IGI]
- blood vessel morphogenesis [IMP]
- cell migration [IBA]
- cell surface receptor signaling pathway [IDA, IMP]
- cellular response to molecule of fungal origin [IMP]
- defense response to bacterium [IMP]
- enzyme linked receptor protein signaling pathway [IDA]
- innate immune response [IMP]
- integrin-mediated signaling pathway [IMP]
- intracellular signal transduction [IDA, IMP]
- leukocyte activation involved in immune response [IMP]
- leukocyte cell-cell adhesion [ISO]
- leukotriene biosynthetic process [IMP]
- lymph vessel development [IMP]
- macrophage activation involved in immune response [IMP]
- neutrophil activation involved in immune response [IMP]
- neutrophil chemotaxis [ISO]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of B cell differentiation [IMP]
- positive regulation of alpha-beta T cell differentiation [IGI]
- positive regulation of alpha-beta T cell proliferation [IGI]
- positive regulation of bone resorption [IMP]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of cell adhesion mediated by integrin [IMP]
- positive regulation of cytokine secretion [IGI]
- positive regulation of gamma-delta T cell differentiation [IMP]
- positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process [IMP]
- positive regulation of interleukin-3 biosynthetic process [IMP]
- positive regulation of mast cell degranulation [IMP, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- protein autophosphorylation [IDA, ISO]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of arachidonic acid secretion [IMP]
- regulation of immune response [ISO]
- regulation of neutrophil degranulation [IMP]
- regulation of phagocytosis [IMP]
- regulation of platelet activation [IMP]
- regulation of platelet aggregation [IMP]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- regulation of superoxide anion generation [IMP]
- serotonin secretion [IMP]
- serotonin secretion by platelet [IMP]
- signal transduction by phosphorylation [IDA]
- transcription factor import into nucleus [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- ATP binding [IDA]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- receptor signaling protein tyrosine kinase activity [IDA]
- ATP binding [IDA]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- receptor signaling protein tyrosine kinase activity [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
CLEC7A
BGR, Clecsf12, beta-GR
C-type lectin domain family 7, member a
GO Process (14)
GO Function (7)
GO Component (1)
Gene Ontology Biological Process
- cell recognition [ISO]
- cell surface pattern recognition receptor signaling pathway [IDA]
- cellular response to molecule of fungal origin [IDA]
- detection of yeast [IDA]
- innate immune response [IDA]
- leukocyte activation involved in immune response [IDA]
- pattern recognition receptor signaling pathway [ISO]
- phagocytosis, engulfment [IDA]
- phagocytosis, recognition [IDA, ISO]
- positive regulation of phagocytosis [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- response to molecule of fungal origin [IDA]
- response to yeast [IDA]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity.
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase, which plays an essential role in both innate and adaptive immunity. However, the key molecular mechanisms that regulate SYK activity are poorly understood. Here we identified the E3 ligase TRIM31 as a crucial regulator of SYK activation. We found that TRIM31 interacted with SYK and catalyzed K27-linked polyubiquitination at Lys375 and ... [more]
Signal Transduct Target Ther Dec. 06, 2020; 6(1);298 [Pubmed: 34362877]
Throughput
- Low Throughput
Curated By
- BioGRID